ÃÛÌÒÓ°Ïñ

Friday 18 October 2024
ÃÛÌÒÓ°Ïñ Foundation Trust

FOI_8035

Internal Reference Number: FOI_8035

Date Request Received: 08/07/2024 00:00:00

Date Request Replied To: 15/07/2024 00:00:00

This response was sent via: By Email

Request Summary: Diffuse Large B Cell Lymphoma (DLBCL)

Request Category: Private Individuals

 
Question Number 1:
In the last 6 months, how many patients have been diagnosed with Diffuse Large B Cell Lymphoma (DLBCL)?

1a. Of these patients, how many commenced treatment at your trust within the last 6 months?
 
Answer To Question 1:
1. 7 patients have been diagnosed with Diffuse Large B Cell Lymphoma.

1a. 6 of the 7 patients diagnosed were treated within the last six months.
 
Question Number 2:
In the last 6 months, how many patients have you treated for Diffuse Large B Cell Lymphoma (DLBCL) with the following treatments:

R-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone)

R-mini-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone)

Pola-BR (polatuzumab vedotin with rituximab and bendamustine)

Pola-R-CHP (Polatuzumab vedotin with rituximab, cyclophosphamide, doxorubicin hydrochloride, and prednisolone)

R-CODOX-M (rituximab, cyclophosphamide, vincristine, doxorubicin and methotrexate)

R-IVAC (rituximab, ifosfamide, etoposide and cytarabine)

Axicabtagene ciloleucel (Yescarta)

Tisagenlecleucel

Epcoritamab

Loncastuximab tesirine

Glofitamab

Any other SACT

Stem cell transplant or bone marrow transplant (autologous or allogeneic)
 
Answer To Question 2:


-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone)

<5 patients.

R-mini-CHOP (rituximab, cyclophosphamide, doxorubicin hydrochloride, vincristine and prednisolone)

<5 patients

Pola-BR (polatuzumab vedotin with rituximab and bendamustine)
<5 patients

Pola-R-CHP (Polatuzumab vedotin with rituximab, cyclophosphamide, doxorubicin hydrochloride, and prednisolone)

6 patients

R-CODOX-M (rituximab, cyclophosphamide, vincristine, doxorubicin and methotrexate)
0 patients

R-IVAC (rituximab, ifosfamide, etoposide and cytarabine)

0 patients

Axicabtagene ciloleucel (Yescarta)
0 patients

Tisagenlecleucel

0 patients

Epcoritamab

<5 patients

Loncastuximab tesirine

0 patients

Glofitamab

0 patients

Any other SACT

<5 patients

Stem cell transplant or bone marrow transplant (autologous or allogeneic) - These are referred to UHS - please contact Southampton for information if required: freedomofinformation@uhs.nhs.uk
 
Question Number 3:
In the last 6 months, how many patients have received the following 2nd line treatments for Diffuse Large B Cell Lymphoma (DLBCL):

Axicabtagene ciloleucel (Yescarta)

Tisagenlecleucel

Pola-BR (polatuzumab vedotin with rituximab and bendamustine)

Stem cell transplant or bone marrow transplant (autologous or allogeneic)

Any other treatments
 
Answer To Question 3:
Axicabtagene ciloleucel (Yescarta)

Tisagenlecleucel

0 patients

Pola-BR (polatuzumab vedotin with rituximab and bendamustine)

<5 patients

Stem cell transplant or bone marrow transplant (autologous or allogeneic)

Not currently being done on site. 0 patients. These are referred to UHS - please contact Southampton for information if required: freedomofinformation@uhs.nhs.uk

Any other treatments

<5
 
Question Number 4:
In the last 6 months, how many patients have you referred to other trusts for the treatment of Diffuse Large B Cell Lymphoma (DLBCL) for the following treatments:

CAR-T Therapy (E.g. Axicabtagene ciloleucel)

Stem cell transplant or bone marrow transplant (autologous or allogeneic)

Any other treatment
 
Answer To Question 4:

CAR-T Therapy (E.g. Axicabtagene ciloleucel) <5

Stem cell transplant or bone marrow transplant (autologous or allogeneic) These are referred to UHS - please contact Southampton for information if required: freedomofinformation@uhs.nhs.uk

Any other treatment - CNS DLBCL <5 patients
 
Question Number 5:
Do you participate in any active clinical trials for Diffuse Large B-Cell Lymphoma (DLBCL)? If so, can you please provide the name of each trial along with the number of patients taking part or enrolling?
 
Answer To Question 5:
No active DLBCL trials at present
 
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